讲述在三国时期战乱四起，年轻的华佗在家乡杭州给所有的百姓看病，过着平静安逸的生活。华佗凭借超高的医术让太守的女儿明心起死回生，因此拥有神医的美名，也与明心产生纠葛，此时为了研制麻沸散给明心治疗眼疾，开始四处游历寻找药物，华佗在都城与英雄关羽、曹操以及师兄吴思德发生交集，见识到人心的险恶和世态炎凉，最让人接受不了的是心爱的姑娘明心却遭吴思德的霸占。内心绝望的华佗在东昊山中，受到高人指点，幡然醒悟立志要成为济世悬壶救人的大医。通过赤壁之战，刮骨疗伤，华佗经历各种险境，任凭任何的苦难也不会更改华佗内心拯救沧桑的愿望，随着麻沸散研制的成功，也最终让华佗与明心修成正果，就在幸福到来之时，曹操将华佗抓走，使这位妙手回春的大医直接死在狱中

It tells the story of wars and turmoil during the Three Kingdoms period. The young Hua Tuo treated all the people in his hometown of Hangzhou and lived a peaceful and comfortable life. Hua Tuo brought the prefect's daughter Ming Xin back to life by virtue of his superb medical skills. Therefore, he gained the reputation of a miracle doctor and had disputes with Ming Xin. Intersecting heroes Guan Yu, Cao Cao and senior brother Wu Side in the capital, and seeing the sinister human heart and the cruelty of the world, the most unacceptable thing is that the beloved girl Mingxin is occupied by Wu Side. Hua Tuo, who was in despair, was instructed by an expert in Donghao Mountain, and suddenly realized that he was determined to become a great doctor who can save the world and save people. Through the Battle of Chibi, Hua Tuo experienced various dangers, and no matter what kind of suffering, Hua Tuo's inner desire to save the vicissitudes will not be changed. When the cultivation was successful, when happiness came, Cao Cao took Hua Tuo away, causing the rejuvenated doctor to die in prison