《当家主母》讲述任家的家主富人沈翠喜，凭借自己高超的技艺和豁达的胸襟，帮助家族一次次化解危机，带领任家走向辉煌的故事。为了将祖宗的手艺发扬光大。她开办学室，教授自己家族的女子们学习手艺，带领她们走向自立自强的道路，成为独当一面的女强人

电视剧开始，苏州府的任家便在苏州世袭带领制造行领织，任家拥有祖传的缫丝秘籍，织就出来的丝线坚韧异常且十分华美，技艺高超。但是任家的家主却从来不过问家族生意，他平时只研究诗词书画。这一切责任便落到了任夫人的肩上，任夫人不但刺绣功夫了得，更擅长经营管理，任家的生意能够遍布天下，全凭借沈翠喜的张罗，但是沈翠喜和任家家主结婚多年。家主却始终惦记着自己曾经的爱人曾宝琴，最终两个人产生矛盾。

"The Mistress of the House" tells the story of Shen Cuixi, the wealthy head of the Ren family, who helps the family resolve crises time after time by virtue of her superb skills and open-mindedness. The story of leading the Ren family to glory. In order to carry forward the craftsmanship of the ancestors. She opened a school to teach the women of her family skills, leading them to the road of self-reliance and self-improvement, and becoming a strong woman in their own right

Since the beginning of the TV series, the Ren family of Suzhou Prefecture has hereditaryly led the manufacture of collar weaving in Suzhou. The silk thread weaved out is extremely tough and very gorgeous, with superb skills. But the head of the Ren family never cared about the family business. He usually only studies poetry, calligraphy and painting. All these responsibilities fell on Mrs. Ren's shoulders. Mrs. Ren is not only good at embroidery, but also good at management. The Ren family's business can spread all over the world, all thanks to Shen Cuixi's efforts, but Shen Cuixi and the head of the Ren family have been married for many years. The head of the family always misses his former lover Zeng Baoqin, and eventually the two have conflicts.