该影片讲述的是特工队在寻找被盗的致命病毒，特工组成员接二连三被杀害，特工队受到了前所未有的压迫，伊森经过深入的调查，发现这是恐怖分子头目肖恩.安布罗斯精心策划的阴谋，陆瑟和伊森两个老搭档开始了全程追踪肖恩的艰辛过程

剧情是由一位医学博士研究出一种威力巨大的新型病毒而展开。前来接应病毒安全保送的特工，在途中被肖恩谋害，肖恩盗取了病毒资料，伊森接到命令，需要找到肖恩并将情报资料夺回。伊森想要夺回病毒资料就必须找到神偷奈雅的帮助，奈雅是最适合接近肖恩的人选，因为奈雅是肖恩的前女友。在与奈雅的接触过程中两人产生了不一样的情愫，奈雅也成功的帮助了伊森完成了任务，同时也深陷险境，将病毒注射到了自己的体内，伊森为了夺回解药和病毒与恩森开始了激烈的搏斗。

The film tells the story of the secret service team searching for the stolen deadly virus. After an in-depth investigation, Sen found out that this was a conspiracy carefully planned by the terrorist leader Sean Ambrose. Two old partners, Lu Se and Ethan, started the arduous process of tracking Sean the whole way

The plot begins with a doctor of medicine researching a powerful new virus. The agent who came to meet the security escort of the virus was murdered by Sean on the way. Sean stole the virus information. Ethan was ordered to find Sean and retrieve the information. If Ethan wants to get back the viral data, he must find the help of the thief Naia, who is the most suitable person to approach Sean, because Naia is Sean's ex-girlfriend. During the contact with Naiya, the two had different feelings. Naiya also successfully helped Ethan complete the task, but at the same time fell into danger and injected the virus into his body. In order to get back the antidote, Ethan Started a fierce fight with Virus and Ensen.