科学家塞巴斯蒂安-凯恩（凯文-贝肯饰）领导着一个小组，专门研究隐身药剂。凯恩醉心于研究，有时甚至陷入了疯狂。在他的带领下，小组终于研究出隐身试剂，他们在动物身上做试验，并获得了成功。凯恩不满足只在动物身上试验，而想把这种试剂用在人身上。最终凯恩偷偷在自己身上用了隐身试剂，但他却无法恢复人形。刚开始成为隐形人的凯恩非常焦虑，但后来他发现隐身给他带来很多便利，他越来越享受这种隐身的感觉。此时小组其他组员琳达（伊丽莎白-苏）和马修-肯辛顿（乔什-布洛林饰）为了救凯恩正在研制解药，凯恩却觉得这对他来说是种威胁。凯恩为了阻止解药的研制成功陷入了疯狂，他甚至杀死他的上司霍华德-克莱默博士（威廉-德瓦内饰）和医生希拉（金-迪金斯饰）

Scientist Sebastian Kane (Kevin Bacon) leads a team that specializes in invisibility potions. Kane was obsessed with research, and sometimes even fell into madness. Under his leadership, the group finally developed a stealth reagent, which they tested on animals and succeeded. Kane was not content to test only on animals, but wanted to use the reagent on humans. In the end, Kane secretly used the invisibility reagent on himself, but he was unable to restore his human form. Kane, who first became an invisible man, was very anxious, but later he found that invisibility brought him a lot of convenience, and he enjoyed this feeling of invisibility more and more. At this time, the other team members Linda (Elizabeth Sue) and Matthew Kensington (Josh Brolin) are developing an antidote to save Kane, but Kane feels that this is a threat to him. . Kane went into a frenzy to prevent the successful development of the antidote, and he even killed his boss, Dr. Howard Kramer (William DeVine) and doctor Sheila (Kim Deakins)