《无问西东》东分别讲述了四个不同时代出自清华的学生命运。文革期间王敏佳（章子怡饰）为被批斗的老师出头而陷入政治漩涡，因此被毁容，面对喜欢她的陈鹏（黄晓明饰）的表白，因为自卑差点错过。后来陈鹏带着王敏佳回到家乡，并远赴大西北研制原子弹。生活在21世纪的张果果（张震饰）是一家广告公司的高管，他曾经向生病的四胞胎父母承诺，帮他们争取手术费用，但是后来给与他们帮助后，他怀疑对方赖上了他，最后他在工作中遭到上司的设计，被迫离职。解放前出身良好的富家子弟沈光耀（王力宏饰）在国家危难之时，毅然弃文从军，参加飞行员的选拔，为祖国奉献自己的青春。清华文学学霸吴岭澜（陈楚生饰）读书时意气风发，但是当时的社会环境推崇“理科才是实业”。他改文从理，却陷入了迷茫，后来在校长梅贻琦的鼓励下找回自我

"Wuwen Xidong" respectively tells the fate of students from Tsinghua University in four different eras. During the Cultural Revolution, Wang Minjia (played by Zhang Ziyi) fell into a political vortex because of the criticism of her teacher, so she was disfigured. Facing the confession of Chen Peng (played by Huang Xiaoming), who liked her, she almost missed it because of her inferiority complex. Later, Chen Peng took Wang Minjia back to his hometown and went to the Northwest to develop an atomic bomb. Living in the 21st century, Zhang Guoguo (played by Zhang Zhen) is an executive of an advertising company. He once promised the sick parents of quadruplets to help them obtain surgery expenses, but after helping them, he suspected that the other party was relying on him. In the end, he was designed by his boss at work and was forced to resign. Shen Guangyao (played by Wang Leehom), a son of a well-born rich family before liberation, resolutely abandoned his career and joined the army when the country was in distress, participated in the selection of pilots, and dedicated his youth to the motherland. Wu Linglan (played by Chen Chusheng), a literary master at Tsinghua University, was full of enthusiasm when he was studying, but the social environment at that time respected "science is business". He switched from writing to science, but fell into confusion. Later, with the encouragement of the principal Mei Yiqi, he found himself