本是哥谭市阿卡姆疯人院心理医生的哈莉▪奎茵爱上了自己的病人小丑，为了获得小丑的爱恋，她帮小丑逃出了疯人院，飙车，不惜跳进危险的化工池……最终让小丑爱上了自己。他们在哥谭市横行霸道，成为哥谭市的梦魇。蝙蝠侠开始追击他们，小丑逃掉，哈莉被蝙蝠侠抓进了这所特别监狱。得知消息的小丑抓来了黑监狱的狱长，吓怂了的监狱长道出了政府的一项秘密计划：他们抓来穷凶极恶的危险分子，组成残暴的刺杀小队，专门去执行政府不能出面的见不得人的谋杀，为了让这些人听从命令，他们还在这些残暴分子脖子中植入遥控的纳米炸弹，一旦这些人逃跑或不能完成任务，就会被炸死。哈莉被选中成为这支自杀小队的一分子。自杀小队带着各自挑选的武器，来到已是一片废墟的市中心执行任务，同一群长相怪异的生物展开了激烈的交战……与此同时，小丑也带着手下来到蝙蝠侠实验室，开启了营救哈莉之路…

Harley Quinn, a psychiatrist at Arkham Asylum in Gotham City, fell in love with her patient, the clown. In order to get the love of the clown, She helped the clown escape from the lunatic asylum, dragged the car, and jumped into the dangerous chemical pool... and finally made the clown fall in love with herself. They run rampant in Gotham City and become the nightmare of Gotham City. Batman started chasing them, Joker escaped, and Harley was caught by Batman and put into this special prison. The clown who got the news captured the warden of the black prison, and the frightened warden revealed a secret plan of the government: They captured the vicious and dangerous elements and formed a brutal assassination team to execute the crimes that the government could not come forward to. In order to make these people obey orders, they also implanted remote-controlled nano-bombs in the necks of these brutal elements. Once these people escape or fail to complete their tasks, they will be killed. Halle was chosen to be part of the Suicide Squad. The suicide squad came to the ruined city center with their weapons of choice to carry out their mission, and fought fiercely with a group of weird-looking creatures... At the same time, the clown also brought his men down to Batman's laboratory to start On the way to rescue Harley..